https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Structure-relaxivity mechanism of an ultrasmall ferrite nanoparticle T-1 MR contrast agent: The impact of dopants controlled crystalline core and surface disordered shell https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39803 1 nanoprobe for noninvasive visualization of biological events. However, the structure–relaxivity relationship and regulatory mechanism of UFNPs remain elusive. Herein, we developed chemically engineered 3.8 nm ZnxFe3–xO4@ZnxMnyFe3–x–x–yO4 (denoted as ZnxF@Zn4Mn4F) nanoparticles with precise dopants control in both crystalline core and disordered shell as a model system to assess the impact of dopants on the relaxometric properties of UFNPs. It is determined that the core–shell dopant architecture allows the optimal tuning of r1 relaxivity for Z0.40.4F@Zn0.40.4Mn0.2F up to 20.22 mM–1 s–1, which is 5.2-fold and 6.5-fold larger than that of the original UFNPs and the clinically used Gd-DTPA. Moreover, the high-performing UFNPs nanoprobe, when conjugated with a targeting moiety AMD3100, enables the in vivo MRI detection of small lung metastasis with greatly enhanced sensitivity. Our results pave the way toward the chemical design of ultrasensitive T1 nanoprobe for advanced molecular imaging.]]> Wed 10 Aug 2022 13:11:25 AEST ]]> Centrifuge model testing of a loess landslide induced by rising groundwater in Northwest China https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48366 Mon 13 Nov 2023 08:51:40 AEDT ]]> Model test study on the hydrological mechanisms and early warning thresholds for loess fill slope failure induced by rainfall https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46854 Fri 30 Jun 2023 10:45:21 AEST ]]> Centrifuge model testing of Loess landslides induced by excavation in Northwest China https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38213 Fri 13 Aug 2021 14:03:42 AEST ]]>